eScience, or enabling science, involves the theory and practice of how to enable scientists from different domains to take advantage of the latest advancements in computer science and technology. This is mainly achieved via science gateways, also known as virtual research environments, which hide the technical details of accessing and exploiting available infrastructures by exposing only domain-specific concepts understandable by the scientists (end-users). Currently at the AMC, the eScience team (http://www.ebioscience.amc.nl) supports biologists at the radiology and biochemistry departments, among others, by developing customized science gateways. In this talk, I will reflect upon the experiences and advancements of the eScience team in the past years.